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1

Localization of Leptin Binding Domain in the Leptin Receptor

Fong, Tung Ming, Huang, Ruey-Ruey C., Tota, Michael R., Mao, Cheri, Smith, Tim, Varnerin, Jeff, Karpitskiy, Vladimir V., Krause, James E., Van der Ploeg, Lex H. T.

Journal:

Molecular Pharmacology

Year:

1998

Language:

english

File:

PDF, 196 KB

english, 1998

2

Plasma and Red Blood Cell Membrane Accretion and Pharmacokinetics of RT001 (bis-Allylic 11,11-D2-Linoleic Acid Ethyl Ester) during Long Term Dosing in Patients

Brenna, J. Thomas, James, Genevieve, Midei, Mark, Heerinckx, Frederic, Atwal, Paldeep, Milner, Peter, Schmidt, Karsten, van der Ploeg, Lex, Fielding, Robert, Shchepinov, Mikhail S.

Journal:

Journal of Pharmaceutical Sciences

Year:

2020

File:

PDF, 877 KB

2020

3

Evolutionary Relationship of the Ligand-Gated Ion Channels and the Avermectin-Sensitive, Glutamate-Gated Chloride Channels

Demetrios K. Vassilatis, Keith O. Elliston, Philip S. Paress, Michel Hamelin, Joseph P. Arena, James M. Schaeffer, Lex H.T. Van der Ploeg, Doris F. Cully

Journal:

Journal of Molecular Evolution

Year:

1997

Language:

english

File:

PDF, 231 KB

english, 1997

4

Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

Wong, Philip C., Zheng, Hui, Chen, Hua, Becher, Mark W., Sirinathsinghji, Dalip J. S., Trumbauer, Myrna E., Chen, Howard Y., Price, Donald L., Van der Ploeg, Lex H. T., Sisodia, Sangram S.

Journal:

Year:

1997

File:

PDF, 2.28 MB

1997

5

Epidemiological study air disaster in Amsterdam (ESADA): study design

Pauline Slottje, Anja C Huizink, Jos WR Twisk, Anke B Witteveen, Henk M van der Ploeg, Inge Bramsen, Nynke Smidt, Joost A Bijlsma, Lex M Bouter, Willem van Mechelen, Tjabe Smid

Journal:

BMC Public Health

Year:

2005

Language:

english

File:

PDF, 319 KB

english, 2005

6

Analogs of Lactam Derivatives of α-Melanotropin with Basic and Acidic Residues

Maria A. Bednarek, Tanya MacNeil, Rubana N. Kalyani, Rui Tang, Lex H.T. Van der Ploeg, David H. Weinberg

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 63 KB

english, 2000

7

Like falling off…

Van der Ploeg, Lex H.T.

Journal:

Year:

2006

Language:

english

File:

PDF, 356 KB

english, 2006

8

Molecular Determinants of Ligand Binding to the Human Melanocortin-4 Receptor †

Yang, Ying-kui, Fong, Tung M., Dickinson, Chris J., Mao, Cheri, Li, Ji-Yao, Tota, Michael R., Mosley, Ralph, Van der Ploeg, Lex H. T., Gantz, Ira

Journal:

Year:

2000

Language:

english

File:

PDF, 171 KB

english, 2000

9

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

Clément, Karine, Biebermann, Heike, Farooqi, I. Sadaf, Van der Ploeg, Lex, Wolters, Barbara, Poitou, Christine, Puder, Lia, Fiedorek, Fred, Gottesdiener, Keith, Kleinau, Gunnar, Heyder, Nicolas, Schee

Journal:

Nature Medicine

Year:

2018

Language:

english

File:

PDF, 1.29 MB

english, 2018

10

Preparation of Functionally Active [35S]Leptin for Mapping Its Receptors in the Brain

Xiao-Ming Guan, Hong Yu, Lex H.T. Van der Ploeg, Roy G. Smith

Journal:

Analytical Biochemistry

Year:

1997

Language:

english

File:

PDF, 863 KB

english, 1997

11

Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands

Raman K. Bakshi, Qingmei Hong, Rui Tang, Rubana N. Kalyani, Tanya MacNeil, David H. Weinberg, Lex H.T. Van der Ploeg, Arthur A. Patchett, Ravi P. Nargund

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 122 KB

english, 2006

12

Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant

Ihor E. Kopka, Linus S. Lin, James P. Jewell, Thomas J. Lanza, Tung M. Fong, Chun-Pyn Shen, Zhege J. Lao, Sookhee Ha, Laurie G. Castonguay, Lex Van der Ploeg, Mark T. Goulet, William K. Hagmann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1000 KB

english, 2010

13

Spiro(indoline-3,4′-piperidine) growth hormone secretagogues as ghrelin mimetics

Brenda L. Palucki, Scott D. Feighner, Sheng-Shung Pong, Karen Kulju McKee, Donna L. Hreniuk, Carina Tan, Andrew D. Howard, Lex H.Y. Van der Ploeg, Arthur A. Patchett, Ravi P. Nargund

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 121 KB

english, 2001

14

Obesity: an epidemic in need of therapeutics

Lex HT Van der Ploeg

Journal:

Current Opinion in Chemical Biology

Year:

2000

Language:

english

File:

PDF, 139 KB

english, 2000

15

Reviews

H. -A. Wagener, Lex Hoogduin, Harry Garretsen, H. Visser, P. L. C. Hilbers, F. M. Tempelaar, Charles van Marrewijk, Georg Tillmann, Fredderick van der Ploeg, R. P. Zuidema, A. R. Thurik, A. Heertje, R

Journal:

Year:

1990

Language:

english

File:

PDF, 2.60 MB

english, 1990

16

Design and syntheses of melanocortin subtype-4 receptor agonists: evolution of the pyridazinone archetype

Feroze Ujjainwalla, Daniel Warner, Thomas F. Walsh, Matthew J. Wyvratt, Changyou Zhou, Lihu Yang, Rubana N. Kalyani, Tanya MacNeil, Lex H.T. Van der Ploeg, Charles I. Rosenblum, Rui Tang, Aurawan Vong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 220 KB

english, 2003

17

Design and syntheses of melanocortin subtype-4 receptor agonists. Part 2: Discovery of the dihydropyridazinone motif

Feroze Ujjainwalla, Daniel Warner, Christine Snedden, Ricky D. Grisson, Thomas F. Walsh, Matthew J. Wyvratt, Rubana N. Kalyani, Tanya MacNeil, Rui Tang, David H. Weinberg, Lex Van der Ploeg, Mark T. G

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 717 KB

english, 2005

18

Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans

Cully, Doris F., Vassilatis, Demetrios K., Liu, Ken K., Paress, Philip S., Van der Ploeg, Lex H. T., Schaeffer, James M., Arena, Joseph P.

Journal:

Year:

1994

File:

PDF, 816 KB

1994

19

10.1038/79254

Van der Ploeg, Lex H.T., Chen, Airu S., Marsh, Donald J., Trumbauer, Myrna E., Frazier, Easter G., Guan, Xiao-Ming, Yu, Hong, Rosenblum, Charles I., Vongs, Aurawan, Feng, Yue, Cao, Linhai, Metzger, Jo

Journal:

Nature Genetics

Year:

2000

Language:

english

File:

PDF, 341 KB

english, 2000

20

Mutations in Murine Mx1: Effects on Localization and Antiviral Activity

Ellen A. Garber, Donna Lynn Hreniuk, Laurie M. Scheidel, Lex H.T. Van Der Ploeg

Journal:

Year:

1993

File:

PDF, 769 KB

1993

21

Colonies of procyclic Trypanosoma brucei on semi-solid agarose plates

Mary Gwo-Shu Lee, Lex H.T. Van der Ploeg

Journal:

Molecular and Biochemical Parasitology

Year:

1989

Language:

english

File:

PDF, 1.12 MB

english, 1989

22

Size-conserved chromosomes and stability of molecular karyotype in cloned stocks of Leishmania major

Suzanne Holmes Giannini, Saundra S. Curry, Robert B. Tesh, Lex H.T. Van der Ploeg

Journal:

Molecular and Biochemical Parasitology

Year:

1990

Language:

english

File:

PDF, 3.18 MB

english, 1990

23

Structure of a telomeric expression site for variant specific surface antigens in Trypanosoma brucei

Michèle Crozatier, Lex H.T. Van der Ploeg, Patricia J. Johnson, Janet Gommers-Ampt, Piet Borst

Journal:

Molecular and Biochemical Parasitology

Year:

1990

Language:

english

File:

PDF, 1.10 MB

english, 1990

24

Evidence for segmental gene conversion between a cognate hsp70 gene and the temperature-sensitively transcribed hsp70 genes of Trypanosoma brucei

Mary Gwo-Shu Lee, Ramona I. Polvere, Lex H.T. Van der Ploeg

Journal:

Molecular and Biochemical Parasitology

Year:

1990

Language:

english

File:

PDF, 765 KB

english, 1990

25

Transcription of the heat shock 70 locus in Trypanosoma brucei

Mary Gwo-Shu Lee, Lex H.T. Van der Ploeg

Journal:

Molecular and Biochemical Parasitology

Year:

1990

Language:

english

File:

PDF, 970 KB

english, 1990

26

Predicted amino acid sequence and genomic organization of Trypanosoma cruzi hsp 60 genes

Marcia Giambiagi-de Marval, Keith Gottesdiener, Edson Rondinelli, Lex H.T. Van der Ploeg

Journal:

Molecular and Biochemical Parasitology

Year:

1993

Language:

english

File:

PDF, 568 KB

english, 1993

27

Single-stranded DNA-protein binding in the procyclic acidic repetitive protein (PARP) promoter of Trypanosoma brucei

Steven Danilo Brown, Lex H.T. Van der Ploeg

Journal:

Molecular and Biochemical Parasitology

Year:

1994

Language:

english

File:

PDF, 1.10 MB

english, 1994

28

Antigenic variation in African trypanosomes

Lex H.T. Van der Ploeg, Keith Gottesdiener, Mary G-S. Lee

Journal:

Trends in Genetics

Year:

1992

Language:

english

File:

PDF, 650 KB

english, 1992

29

Exploring the site of anorectic action of peripherally administered synthetic melanocortin peptide MT-II in rats

Prashant Trivedi, Michael Jiang, Constantin C Tamvakopoulos, Xiaolan Shen, Hong Yu, Steven Mock, Judy Fenyk-Melody, Lex H.T Van der Ploeg, Xiao-Ming Guan

Journal:

Year:

2003

Language:

english

File:

PDF, 667 KB

english, 2003

30

Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula

William J Martin, Erin McGowan, Doreen E Cashen, Liza T Gantert, Jennifer E Drisko, Gary J Hom, Ravi Nargund, Iyassu Sebhat, Andrew D Howard, Lex H.T Van der Ploeg, D.Euan MacIntyre

Journal:

European Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 306 KB

english, 2002

31

Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats

Lauren P. Shearman, Ramon E. Camacho, D. Sloan Stribling, Dan Zhou, Maria A. Bednarek, Donna L. Hreniuk, Scott D. Feighner, Carina P. Tan, Andrew D. Howard, Lex H.T. Van der Ploeg, D.Euan MacIntyre, G

Journal:

European Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 754 KB

english, 2003

32

Trichinella pseudospiralis secretes a protein related to the Trichinella spiralis 43-kDa glycoprotein

Demetrios K. Vassilatis, Dickson D. Despommier, Ramona I. Polvere, Allen M. Gold, Lex H.T. Van der Ploeg

Journal:

Molecular and Biochemical Parasitology

Year:

1996

Language:

english

File:

PDF, 969 KB

english, 1996

33

Developmental expression of a 43-kDa secreted glycoprotein from Trichinella spiralis

Demetrios K. Vassilatis, Ramona I. Polvere, Dickson D. Despommier, Allen M. Gold, Lex H.T. Van der Ploeg

Journal:

Molecular and Biochemical Parasitology

Year:

1996

Language:

english

File:

PDF, 1.05 MB

english, 1996

34

Distribution of neuromedin U receptor subtype 2 mRNA in the rat brain

Xiao-Ming Guan, Hong Yu, Qingping Jiang, Lex H.T Van der Ploeg, Qinyun Liu

Journal:

Gene Expression Patterns

Year:

2001

Language:

english

File:

PDF, 656 KB

english, 2001

35

The control of variant surface antigen synthesis in trypanosomes

Piet BORST, André BERNARDS, Lex H. T. VAN DER PLOEG, Paul A. M. MICHELS, Alvin Y. C. LIU, Titia DE LANGE, Jan M. KOOTER

Journal:

Year:

1983

Language:

english

File:

PDF, 778 KB

english, 1983

36

ART (Protein Product of Agouti-Related Transcript) as an Antagonist of MC-3 and MC-4 Receptors

Tung Ming Fong, Cheri Mao, Tanya MacNeil, Rubana Kalyani, Tim Smith, David Weinberg, Michael R. Tota, Lex H.T. Van der Ploeg

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 82 KB

english, 1997

37

Analogs of MTII, Lactam Derivatives of α-Melanotropin, Modified at the N-Terminus, and Their Selectivity at Human Melanocortin Receptors 3, 4, and 5

Maria A. Bednarek, Tanya Macneil, Rubana N. Kalyani, Rui Tang, Lex H.T. Van der Ploeg, David H. Weinberg

Journal:

Biochemical and Biophysical Research Communications

Year:

1999

Language:

english

File:

PDF, 54 KB

english, 1999

38

L-152,804: Orally Active and Selective Neuropeptide Y Y5 Receptor Antagonist

Akio Kanatani, Akane Ishihara, Hisashi Iwaasa, Kayo Nakamura, Osamu Okamoto, Masayasu Hidaka, Junko Ito, Takahiro Fukuroda, Douglas J. MacNeil, Lex H.T. Van der Ploeg, Yasuyuki Ishii, Takayoshi Okabe,

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 117 KB

english, 2000

39

Adenosine: A Partial Agonist of the Growth Hormone Secretagogue Receptor

Roy G. Smith, Patrick R. Griffin, Yuan Xu, Alexander G.A. Smith, Ken Liu, Jimmy Calacay, Scott D. Feighner, C.-S. Pong, Denis Leong, Anna Pomés, Kang Cheng, Lex H.T. Van der Ploeg, Andrew D. Howard, J

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 99 KB

english, 2000

40

Potent and Selective Peptide Agonists of α-Melanotropin Action at Human Melanocortin Receptor 4: Their Synthesis and Biological Evaluation in Vitro

Maria A. Bednarek, Tanya MacNeil, Rui Tang, Rubana N. Kalyani, Lex H.T. Van der Ploeg, David H. Weinberg

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 58 KB

english, 2001

41

Properties of Three Baculovirus-Expressing Genes That Encode Insect-Selective Toxins: μ-Aga-IV, As II, and Sh I

Grigori G. Prikhod'ko, Moyra Robson, Jeffrey W. Warmke, Charles J. Cohen, McHardy M. Smith, Peiyi Wang, Vivian Warren, Gregory Kaczorowski, Lex H.T. Van der Ploeg, Lois K. Miller

Journal:

Biological Control

Year:

1996

Language:

english

File:

PDF, 206 KB

english, 1996

42

Cloning and Characterization of Two Human G Protein-Coupled Receptor Genes (GPR38 and GPR39) Related to the Growth Hormone Secretagogue and Neurotensin Receptors

Karen Kulju McKee, Carina P. Tan, Oksana C. Palyha, Jim Liu, Scott D. Feighner, Donna L. Hreniuk, Roy G. Smith, Andrew D. Howard, Lex H.T. Van der Ploeg

Journal:

Year:

1997

Language:

english

File:

PDF, 6.38 MB

english, 1997

43

Novel aspects of accumulation dynamics and Aβ composition in transgenic models of AD

Huw D Lewis, Dirk Beher, David Smith, Louise Hewson, Natalie Cookson, David S Reynolds, Gerard R Dawson, Michael Jiang, Lex H.T Van der Ploeg, Su Qian, Thomas W Rosahl, Raj N Kalaria, Mark S Shearman

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 344 KB

english, 2004

44

Expression, refolding, and purification of recombinant human phosphodiesterase 3B: definition of the N-terminus of the catalytic core

Jeffrey P Varnerin, Christine C Chung, Sangita B Patel, Giovanna Scapin, Emma R Parmee, Nancy R Morin, Douglas J MacNeil, Doris F Cully, Lex H.T Van der Ploeg, Michael R Tota

Journal:

Protein Expression and Purification

Year:

2004

Language:

english

File:

PDF, 726 KB

english, 2004

45

Structure–activity relationship of linear tetrapeptides Tic-DPhe-Arg-Trp-NH2 at the human melanocortin-4 receptor and effects on feeding behaviors in rat

Zhixiong Ye, Tanya MacNeil, David H. Weinberg, Rubana N. Kalyani, Rui Tang, Alison M. Strack, Beth A. Murphy, Ralph T. Mosley, D. Euan MacIntyre, Lex H.T. Van der Ploeg, Arthur A. Patchett, Matthew J.

Journal:

Year:

2005

Language:

english

File:

PDF, 365 KB

english, 2005

46

The role of tryptophan 1072 in human PDE3B inhibitor binding

Christine Chung, Jeffrey P Varnerin, Nancy R Morin, Douglas J MacNeil, Suresh B Singh, Sangita Patel, Giovanna Scapin, Lex H.T Van der Ploeg, Michael R Tota

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 323 KB

english, 2003

47

Molecular cloning and characterization of a new receptor for galanin

Andrew D Howard, Carina Tan, Lin-Lin Shiao, Oksana C Palyha, Karen Kulju McKee, David H Weinberg, Scott D Feighner, Margaret A Cascieri, Roy G Smith, Lex H.T Van Der Ploeg, Kathleen A Sullivan

Journal:

Year:

1997

Language:

english

File:

PDF, 720 KB

english, 1997

48

Molecular analysis of a new splice variant of the human melanocortin-1 receptor

Carina P Tan, Karen Kulju McKee, David H Weinberg, Tanya MacNeil, Oksana C Palyha, Scott D Feighner, Donna L Hreniuk, Lex H.T Van Der Ploeg, Douglas J MacNeil, Andrew D Howard

Journal:

Year:

1999

Language:

english

File:

PDF, 253 KB

english, 1999

49

Orphan G-protein-coupled receptors and natural ligand discovery

Andrew D Howard, George McAllister, Scott D Feighner, Qingyun Liu, Ravi P Nargund, Lex H.T Van der Ploeg, Arthur A Patchett

Journal:

Trends in Pharmacological Sciences

Year:

2001

Language:

english

File:

PDF, 106 KB

english, 2001

50

Characterization of several NPY ligands with cloned murine NPY receptors: ICV administration of a selective Y5 agonist, D-TRP34NPY, induces obesity

Douglas J. MacNeil, Nancy R. Morin, Annette G. Beck-Sickinger, Akio Kanatani, Ahuichi As Asahi, Akane Ishihara, Masaki Ihara, Lex Van der Ploeg

Journal:

Regulatory Peptides

Year:

2000

Language:

english

File:

PDF, 117 KB

english, 2000

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